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Behcet s disease Hirohata S; Kikuchi HArthritis Res Ther 2003[]; 5 (3): 139-46Behcet's disease is characterized by recurrent aphthous stomatitis, uveitis, genital ulcers, and skin lesions. The role of the HLA-B*51 gene has been confirmed in recent years, although its contribution to the overall genetic susceptibility to Behcet's disease was estimated to be only 19%. The production of a variety of cytokines by T cells activated with multiple antigens has been shown to play a pivotal role in the activation of neutrophils. As regards the treatment, anti-tumor necrosis factor alpha therapy has been shown to be effective for mucocutaneous symptoms as well as for sight-threatening panuveitis, although a randomized, controlled trial is required.|Animals[MESH]|Behcet Syndrome/*genetics/therapy[MESH]|Genetic Predisposition to Disease[MESH]|HLA-B Antigens/genetics/physiology[MESH]|HLA-B51 Antigen[MESH]|Humans[MESH] |
