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lüll Caveolin, caveolae, and endothelial cell function Frank PG; Woodman SE; Park DS; Lisanti MPArterioscler Thromb Vasc Biol 2003[Jul]; 23 (7): 1161-8Caveolae are 50- to 100-nm cell-surface plasma membrane invaginations observed in terminally differentiated cells. They are particularly abundant in endothelial cells, where they are believed to play a major role in the regulation of endothelial vesicular trafficking and signal transduction. The use of caveolin-1-deficient mice has provided many new insights into the roles of caveolae and caveolin-1 in the regulation of endothelial cell function. These novel findings suggest an important role for caveolin-1 in the pathogenesis of cancer, atherosclerosis, and vascular disease.|Arteriosclerosis/etiology[MESH]|Capillary Permeability/physiology[MESH]|Caveolae/*physiology[MESH]|Caveolins/*physiology[MESH]|Endothelial Cells/*physiology/ultrastructure[MESH]|Endothelium, Vascular/*cytology[MESH]|Hemorheology[MESH]|Macromolecular Substances[MESH]|Neovascularization, Physiologic/physiology[MESH]|Nitric Oxide Synthase Type III[MESH]|Nitric Oxide Synthase/physiology[MESH]|Signal Transduction/physiology[MESH] |