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Hyaline vascular Castleman s disease: a case report and brief review of the literature van den Berge M; Pauwels P; Jakimowicz JJ; Creemers GJNeth J Med 2002[Dec]; 60 (11): 444-7We describe a 27-year-old female with a mesenterial localisation of the hyaline vascular type of Castleman's disease. A review of the literature is given with emphasis on the different pathogenesis of the subtypes. The hyaline vascular type is a disorder of stromal cells, which can be complicated by the development of soft tissue sarcomas. The plasma cell type is a plasma cell disorder with elevated levels of interleukin-6 (IL-6). In the multicentric type, infection with human herpes virus-8 (HHV-8) plays an important role in the pathogenesis. The development of Kaposi's sarcoma and some lymphomas are related to the presence of HHV-8. As the different subtypes have a different pathogenesis they should be regarded as distinct diseases.|Adult[MESH]|Castleman Disease/immunology/*pathology/therapy/virology[MESH]|Female[MESH]|Herpesvirus 8, Human[MESH]|Humans[MESH]|Interleukin-6/blood[MESH]|Sarcoma, Kaposi/complications[MESH]|Tomography, X-Ray Computed[MESH] |
