Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll The role of Apaf-1 in programmed cell death: from worm to tumor Yoshida HCell Struct Funct 2003[Feb]; 28 (1): 3-9Apoptosis or programmed cell death is an important process to eliminate unnecessary or hazardous cells. Apaf-1, a mammalian homologue of CED-4 of C. elegans, is the essential adaptor molecule in the mitochondrial pathway of apoptosis. Mice lacking Apaf-1 show accumulation of neurons in the developing central nervous system due to reduced apoptosis. Apaf-1-deficient cells are remarkably resistant to various apoptotic stimuli. Apaf-1-mediated apoptosis plays a role in the prevention of tumorigenesis. However, Apaf-1-independent cell death pathways are also indicated. In this review, we will summarize what has been learned about the role of Apaf-1 by biochemical and genetical approaches.|Animals[MESH]|Apoptosis/*physiology[MESH]|Apoptotic Protease-Activating Factor 1[MESH]|Caenorhabditis elegans Proteins/genetics/metabolism[MESH]|Cell Transformation, Neoplastic/genetics/metabolism[MESH]|Eukaryotic Cells/cytology/*metabolism[MESH]|Humans[MESH]|Mitochondria/genetics/*metabolism[MESH]|Proteins/*genetics/*metabolism[MESH]|Signal Transduction/physiology[MESH] |