Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Sp1- and Kruppel-like transcription factors Kaczynski J; Cook T; Urrutia RGenome Biol 2003[]; 4 (2): 206Sp1-like proteins and Kruppel-like factors (KLFs) are highly related zinc-finger proteins that are important components of the eukaryotic cellular transcriptional machinery. By regulating the expression of a large number of genes that have GC-rich promoters, Sp1-like/KLF transcription regulators may take part in virtually all facets of cellular function, including cell proliferation, apoptosis, differentiation, and neoplastic transformation. Individual members of the Sp1-like/KLF family can function as activators or repressors depending on which promoter they bind and the coregulators with which they interact. A long-standing research aim has been to define the mechanisms by which Sp1-like factors and KLFs regulate gene expression and cellular function in a cell- and promoter-specific manner. Most members of this family have been identified in mammals, with at least 21 Sp1-like/KLF proteins encoded in the human genome, and members are also found in frogs, worms and flies. Sp1-like/KLF proteins have highly conserved carboxy-terminal zinc-finger domains that function in DNA binding. The amino terminus, containing the transcription activation domain, can vary significantly between family members.|*Repressor Proteins[MESH]|Amino Acid Sequence[MESH]|Animals[MESH]|Binding Sites/genetics[MESH]|DNA-Binding Proteins/*genetics[MESH]|Evolution, Molecular[MESH]|Gene Expression Regulation[MESH]|Humans[MESH]|Kruppel-Like Transcription Factors[MESH]|Molecular Sequence Data[MESH]|Phylogeny[MESH]|Sequence Homology, Amino Acid[MESH]|Sp1 Transcription Factor/*genetics[MESH]|Transcription Factors/*genetics[MESH]|Transcription, Genetic/genetics[MESH]|Zinc Fingers/*genetics[MESH] |