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lüll International Union of Pharmacology XXXVI Current status of the nomenclature for receptors for corticotropin-releasing factor and their ligands Hauger RL; Grigoriadis DE; Dallman MF; Plotsky PM; Vale WW; Dautzenberg FMPharmacol Rev 2003[Mar]; 55 (1): 21-6Receptors for corticotropin-releasing factor (CRF) are members of a family of G protein-coupled receptors ("Family B") that respond to a variety of structurally dissimilar releasing factors, neuropeptides, and hormones (including secretin, growth hormone-releasing factor, calcitonin, parathyroid hormone, pituitary adenylate cyclase-activating polypeptide, and vasoactive intestinal polypeptide) and signal through the cyclic AMP and/or calcium pathways. To date, three genes encoding additional CRF-like peptides (urocortins) have been identified in mammals. The urocortins and CRF bind with differential ligand selectivity at the two mammalian CRF receptors. This report was prepared by the International Union of Pharmacology Subcommittee on CRF Receptors, to summarize the current state of CRF receptor biology and to propose changes in the classification and nomenclature of CRF ligands and receptors.|*Terminology as Topic[MESH]|Amino Acid Sequence[MESH]|Animals[MESH]|Humans[MESH]|International Agencies[MESH]|Ligands[MESH]|Molecular Sequence Data[MESH]|Receptors, Corticotropin-Releasing Hormone/chemistry/*classification[MESH]|Sequence Alignment[MESH] |