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  • Platelet activation and the formation of the platelet plug: deficiency of ADAMTS13 causes thrombotic thrombocytopenic purpura
  • Tsai HM
  • Arterioscler Thromb Vasc Biol 2003[Mar]; 23 (3): 388-96
  • In the circulation, a plasma metalloprotease, ADAMTS13, cleaves von Willebrand factor (vWF) in a shear-dependent manner. This article reviews the role of this cleavage in regulating vWF-platelet interaction and proposes a scheme for understanding how a deficiency of ADAMTS13 results in the development of microthrombi in patients with thrombotic thrombocytopenic purpura.
  • |*Platelet Activation[MESH]
  • |ADAM Proteins[MESH]
  • |ADAMTS13 Protein[MESH]
  • |Child[MESH]
  • |Endoplasmic Reticulum/metabolism[MESH]
  • |Hemolytic-Uremic Syndrome/physiopathology[MESH]
  • |Humans[MESH]
  • |Metalloendopeptidases/*deficiency/genetics[MESH]
  • |Mutation[MESH]
  • |Purpura, Thrombotic Thrombocytopenic/diagnosis/*etiology/*metabolism[MESH]
  • |Stress, Mechanical[MESH]
  • |Thrombosis/metabolism[MESH]
  • |von Willebrand Factor/metabolism[MESH]





  • *{{pmid12615692}}
    *<b>[http://www.kidney.de/mlpefetch.php?search=12615692 Platelet activation and the formation of the platelet plug: deficiency of ADAMTS13 causes thrombotic thrombocytopenic purpura ]</b> Arterioscler Thromb Vasc Biol 2003; 23(3) ; 388-96 Tsai HM

        *12615692*

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    Arterioscler Thromb Vasc Biol

    388 3.23 2003