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lüll Sticky business: orchestrating cellular signals at adherens junctions Perez-Moreno M; Jamora C; Fuchs ECell 2003[Feb]; 112 (4): 535-48Cohesive sheets of epithelial cells are a fundamental feature of multicellular organisms and are largely a product of the varied functions of adherens junctions. These junctions and their cytoskeletal associations contribute heavily to the distinct shapes, polarity, spatially oriented mitotic spindle planes, and cellular movements of developing tissues. Deciphering the underlying mechanisms that govern these conserved cellular rearrangements is a prerequisite to understanding vertebrate morphogenesis.|*Adherens Junctions[MESH]|*Signal Transduction[MESH]|Actins/metabolism[MESH]|Animals[MESH]|Cadherins/metabolism[MESH]|Cell Division[MESH]|Cytoskeleton/metabolism[MESH]|Down-Regulation[MESH]|Epithelial Cells[MESH]|Epithelium/physiology[MESH]|Fungal Proteins/metabolism[MESH]|GTP Phosphohydrolases/metabolism[MESH]|Humans[MESH]|Microscopy, Fluorescence[MESH]|Models, Biological[MESH]|Mutation[MESH]|Phosphorylation[MESH]|rhoA GTP-Binding Protein/metabolism[MESH] |