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lüll Membrane domains in the secretory and endocytic pathways Pfeffer SCell 2003[Feb]; 112 (4): 507-17Progress in identifying, characterizing, and localizing the constituents of distinct membrane bound compartments has revealed a new level of intracellular subcompartmentation. Proteins and lipids are not uniformly distributed in a given organelle, and subdomains are formed by a combination of hierarchical assembly processes and protein exclusion. Thus, functionally distinct specializations of a given organelle are physically segregated to a greater extent than previously believed.|Animals[MESH]|Cell Nucleus/*physiology[MESH]|Endocytosis[MESH]|Endoplasmic Reticulum/*physiology/ultrastructure[MESH]|Endosomes/physiology[MESH]|Golgi Apparatus/*physiology[MESH]|Humans[MESH]|Models, Biological[MESH]|Protein Structure, Tertiary[MESH]|rab GTP-Binding Proteins/metabolism[MESH]|trans-Golgi Network/physiology[MESH] |