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lüll Lysosome-related organelles: a view from immunity and pigmentation Raposo G; Fevrier B; Stoorvogel W; Marks MSCell Struct Funct 2002[Dec]; 27 (6): 443-56Lysosomes are ubiquitous organelles that carry out essential household functions. Certain cell types, however, contain lysosome-related organelles with specialized functions. Their specialized functions are usually reflected by specific morphological and compositional features. A number of diseases that develop due to genetic mutations, pathogen exposure or cell transformation are characterized by dysfunctional lysosomes and/or lysosome-related organelles. In this review we highlight adaptations and malfunction of the endosomal/lysosomal system in normal and pathological situations with special focus on MHC class II compartments in antigen presenting cells and melanosomes in pigment cells.|Animals[MESH]|Antigen-Presenting Cells/*metabolism/ultrastructure[MESH]|Cell Compartmentation/physiology[MESH]|Endosomes/*metabolism/ultrastructure[MESH]|Histocompatibility Antigens Class II/metabolism[MESH]|Humans[MESH]|Lysosomal Storage Diseases/metabolism/physiopathology[MESH]|Lysosomes/genetics/*metabolism[MESH]|Melanocytes/*metabolism/ultrastructure[MESH]|Melanosomes/metabolism/ultrastructure[MESH] |