Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Particle disease A comprehensive theory of periprosthetic osteolysis: a review Gallo J; Kaminek P; Ticha V; Rihakova P; Ditmar RBiomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2002[Dec]; 146 (2): 21-8Aseptic loosening and osteolysis are considered the main long-term problems of hip arthroplasty. Pathogenesis of periprosthetic osteolysis is multifactorial, and both the biological and mechanical factors seem to play an important role. Bearing surfaces continuously generate excessive amounts of micron and submicron particles provoking an adverse inflammatory response of periprosthetic connective tissues. In general, a key role has been attributed to macrophages. Cytokines, growth factors, PGE2, and enzymes are secreted with activated periprosthetic cells resulting in formation of osteolytic granulomas. The final osteolytic step is taken predominantly by osteoclasts which are getting ready for action mainly by an osteoprotegerin ligand (RANKL) and TNFalpha. Rankl is expressed by activated macrophages, osteoblasts, and lymphocytes. In parallel, a repetitive hydraulic effect of the joint fluid is manifested on the susceptible bone.|*Arthroplasty, Replacement, Hip[MESH]|*Prosthesis Failure[MESH]|Bone and Bones/pathology[MESH]|Carrier Proteins/physiology[MESH]|Foreign-Body Reaction/etiology/pathology/*physiopathology[MESH]|Hip Prosthesis/*adverse effects[MESH]|Humans[MESH]|Membrane Glycoproteins/physiology[MESH]|Osteoclasts/physiology[MESH]|Osteolysis/etiology/*physiopathology[MESH]|RANK Ligand[MESH]|Receptor Activator of Nuclear Factor-kappa B[MESH]|Reoperation[MESH]|Signal Transduction[MESH]|Tumor Necrosis Factor-alpha/physiology[MESH] |