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lüll Kombination von Antikoagulanzien und Plattchenfunktionshemmern Weber AAHamostaseologie 2002[Dec]; 22 (4): 174-7Platelets and the coagulation system cannot be regarded as completely separate systems. Both systems become activated upon vessel injury and multiple functional interactions exist. Thus with a combination therapy with anticoagulants and platelet-active drugs, drug interactions relevant for hemostasis must be expected. This includes a synergistic inhibition of the hemostatic system but also possible synergistic effects on bleeding complications. This concise review discusses the clinical efficacy of a combination therapy with anticoagulants and platelet-active drugs in patients with acute coronary syndromes (unstable angina, myocardial infarction).|Angina, Unstable/*drug therapy[MESH]|Anticoagulants/*therapeutic use[MESH]|Drug Therapy, Combination[MESH]|Humans[MESH]|Myocardial Infarction/*drug therapy[MESH]|Platelet Aggregation Inhibitors/*therapeutic use[MESH] |