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Mitogen-activated protein kinases and their role in regulation of cellular processes Strniskova M; Barancik M; Ravingerova TGen Physiol Biophys 2002[Sep]; 21 (3): 231-55Mitogen-activated protein kinases (MAPKs) are evolutionary conserved enzymes connecting cell-surface receptors to critical regulatory targets within cells. The three major MAPK cascades are known, the extracellular signal-regulated protein kinase (ERK) cascade, c-Jun amino-terminal protein kinase/stress-activated protein kinase (JNK/SAPK) cascade and p38-MAPK cascade. This paper is focused on characterization of these MAPK cascades in terms of their distribution and biological role in some pathological processes (apoptosis, hypertrophy) with a special orientation on the role of MAPKs in cardiovascular system during ischemia/reperfusion.|*Homeostasis[MESH]|*JNK Mitogen-Activated Protein Kinases[MESH]|*Signal Transduction[MESH]|Animals[MESH]|Apoptosis[MESH]|Enzyme Activation[MESH]|Enzyme Inhibitors[MESH]|Humans[MESH]|MAP Kinase Kinase 4[MESH]|Mitogen-Activated Protein Kinase Kinases/antagonists & inhibitors/classification/metabolism[MESH]|Mitogen-Activated Protein Kinases/antagonists & inhibitors/*classification/*metabolism[MESH]|Multienzyme Complexes/metabolism[MESH]|Myocardial Ischemia/*metabolism[MESH]|Myocardial Reperfusion Injury/metabolism[MESH]|p38 Mitogen-Activated Protein Kinases[MESH] |
