Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Review of 1027 patients with newly diagnosed multiple myeloma Kyle RA; Gertz MA; Witzig TE; Lust JA; Lacy MQ; Dispenzieri A; Fonseca R; Rajkumar SV; Offord JR; Larson DR; Plevak ME; Therneau TM; Greipp PRMayo Clin Proc 2003[Jan]; 78 (1): 21-33OBJECTIVE: To determine the clinical and laboratory features of newly diagnosed multiple myeloma. PATIENTS AND METHODS: Records of all patients in whom multiple myeloma was initially diagnosed at the Mayo Clinic in Rochester, Minn, from January 1, 1985, to December 31, 1998, were reviewed. RESULTS: Of the 1027 study patients, 2% were younger than 40 years, and 38% were 70 years or older. The median age was 66 years. Anemia was present initially in 73% of patients, hypercalcemia (calcium level > or = 11 mg/dL) in 13%, and a serum creatinine level of 2 mg/dL or more in 19%. The beta2-microglobulin level was increased in 75%. Serum protein electrophoresis revealed a localized band in 82% of patients, and immunoelectrophoresis or immunofixation showed a monoclonal protein in 93%. A monoclonal light chain was found in the urine in 78%. Nonsecretory myeloma was recognized in 3% of patients, whereas light-chain myeloma was present in 20%. Conventional radiographs showed an abnormality in 79%. The plasma cell labeling index was 1% or more in 34% of patients. Multivariate analysis revealed that age, plasma cell labeling index, low platelet count, serum albumin value, and the log of the creatinine value were the most important prognostic factors. CONCLUSION: The median duration of survival was 33 months and did not improve from 1985 through 1998.|Adult[MESH]|Aged[MESH]|Aged, 80 and over[MESH]|Anemia/etiology[MESH]|Blood Protein Electrophoresis[MESH]|Cohort Studies[MESH]|Creatinine/blood[MESH]|Diagnosis, Differential[MESH]|Female[MESH]|Humans[MESH]|Hypercalcemia/etiology[MESH]|Immunoelectrophoresis[MESH]|Male[MESH]|Medical Records[MESH]|Middle Aged[MESH]|Multiple Myeloma/blood/complications/*diagnosis/mortality[MESH]|Multivariate Analysis[MESH]|Paraproteinemias/diagnosis[MESH]|Platelet Count[MESH]|Predictive Value of Tests[MESH]|Prognosis[MESH]|Retrospective Studies[MESH]|Serum Albumin/metabolism[MESH]|Survival Analysis[MESH] |