Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
The histopathologic spectrum of cryofibrinogenemia in four anatomic sites Skin, lung, muscle, and kidney Nash JW; Ross P Jr; Neil Crowson A; Taylor J; Morales JE; Yunger TM; Magro CAm J Clin Pathol 2003[Jan]; 119 (1): 114-22Although the histologic characteristics of cryofibrinogenemia have been described in skin lesions, the literature is largely devoid of descriptions of this disorder in other organs. This series is the first to document the histopathologic manifestations of intrapulmonary, intramuscular, and renal cryofibrinogenemia. We describe the histopathologic manifestations of cryofibrinogenemia in 10 cases with manifestations in 4 organ systems: skin in 7 cases, skeletal muscle in 2, lung in 2, and kidney in 1. Irrespective of anatomic site, all lesions showed an occlusive thrombotic diathesis comprising eosinophilic refractile deposits within vessel lumina with extension into the intima, with or without an accompanying characteristic granulomatous vasculitic component. Ultrastructural examination of the renal deposits showed fibrillary material within glomerular capillary lumina with unique morphologic features not previously described. Analysis of plasma from several cases revealed a cold-precipitable protein, which in most cases included a monoclonal paraprotein. The laboratory and histologic distinctions between cryofibrinogenemia and cryoglobulinemia are addressed. We provide guidelines for the proper handling of patient specimens in the workup of cryofibrinogenemia.|Adult[MESH]|Aged[MESH]|Aged, 80 and over[MESH]|Cryoglobulinemia/blood/*pathology[MESH]|Female[MESH]|Humans[MESH]|Immunoelectrophoresis[MESH]|Immunoglobulin G/immunology[MESH]|Immunoglobulin kappa-Chains/analysis[MESH]|Infant[MESH]|Kidney Diseases/blood/*pathology[MESH]|Lung Diseases/blood/*pathology[MESH]|Male[MESH]|Middle Aged[MESH]|Muscular Diseases/blood/*pathology[MESH]|Paraproteins/analysis[MESH]|Skin Diseases/blood/*pathology[MESH] |
