Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Dimerization, translocation and localization of Ku70 and Ku80 proteins Koike MJ Radiat Res 2002[Sep]; 43 (3): 223-36The Ku protein is a complex of two subunits, Ku70 and Ku80, and was originally identified as an autoantigen recognized by the sera of patients with autoimmune diseases. The Ku protein plays a key role in multiple nuclear processes, e.g., DNA repair, chromosome maintenance, transcription regulation, and V(D)J recombination. The mechanism underlying the regulation of all the diverse functions of Ku is still unclear, although it seems that Ku is a multifunctional protein that works in nuclei. On the other hand, several studies have reported cytoplasmic or cell surface localization of Ku in various cell types. To clarify the fundamental characteristics of Ku, we have examined the expression, heterodimerization, subcellular localization, chromosome location, and molecular mechanisms of the nuclear transport of Ku70 and Ku80. The mechanism that regulates for nuclear localization of Ku70 and Ku80 appears to play, at least in part, a key role in regulating the physiological function of Ku in vivo.|*Antigens, Nuclear[MESH]|*DNA Helicases[MESH]|Amino Acid Sequence/genetics[MESH]|Animals[MESH]|Biological Transport[MESH]|Cell Nucleus/*metabolism[MESH]|Chromosome Mapping[MESH]|DNA-Binding Proteins/*chemistry/genetics/*metabolism[MESH]|Dimerization[MESH]|Humans[MESH]|Ku Autoantigen[MESH]|Molecular Sequence Data[MESH]|Nuclear Proteins/*chemistry/genetics/*metabolism[MESH]|Protein Isoforms/chemistry/genetics/metabolism[MESH] |