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Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm Newton ACBiochem J 2003[Mar]; 370 (Pt 2): 361-71Phosphorylation plays a central role in regulating the activation and signalling lifetime of protein kinases A, B (also known as Akt) and C. These kinases share three conserved phosphorylation motifs: the activation loop segment, the turn motif and the hydrophobic motif. This review focuses on how phosphorylation at each of these sites regulates the maturation, signalling and down-regulation of PKC as a paradigm for how these sites control the function of the ABC kinases.|3-Phosphoinositide-Dependent Protein Kinases[MESH]|Amino Acid Motifs[MESH]|Animals[MESH]|Enzyme Activation[MESH]|HSP70 Heat-Shock Proteins/metabolism[MESH]|Humans[MESH]|Isoenzymes/chemistry/metabolism[MESH]|Phosphorylation[MESH]|Protein Kinase C/chemistry/*metabolism[MESH]|Protein Processing, Post-Translational/physiology[MESH]|Protein Serine-Threonine Kinases/metabolism[MESH] |
