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lüll Infusion reactions to infliximab in children and adolescents: frequency, outcome and a predictive model Crandall WV; Mackner LMAliment Pharmacol Ther 2003[Jan]; 17 (1): 75-84BACKGROUND: Crohn's disease commonly affects children and adolescents, however the majority of research into the safety and efficacy of therapies for inflammatory bowel disease, including infliximab, has occurred only in adults. AIM: To determine the rate of reactions in children following infliximab infusions, and to identify variables that might be predictive of those reactions. METHODS: We performed a retrospective review of all infliximab infusions performed at Columbus Children's Hospital from December 1998 through September 2001. RESULTS: Fifty-seven children received 361 infusions. Three hundred and fifty-five of the 361 infusions (98.3%) were completed. Fifty children had 304 repeat infusions. There were a total of 35 infusion related reactions. Female gender and the use of immunosuppressive medications for less than 4 months were risk factors for a reaction to infusion number 2. A reaction to infusion 2 and immunosuppressive use for less than 4 months were risk factors for infusion number 3. CONCLUSIONS: The rate of infusion reactions in children receiving infliximab is similar to that in adults. Female gender, immunosuppressive use for less than 4 months and prior infusion reactions may be risk factors for subsequent infusion reactions in children.|Adolescent[MESH]|Antibodies, Monoclonal/administration & dosage/*adverse effects[MESH]|Antirheumatic Agents/administration & dosage/*adverse effects[MESH]|Arthritis, Rheumatoid/*drug therapy[MESH]|Child[MESH]|Colitis, Ulcerative/*drug therapy[MESH]|Crohn Disease/*drug therapy[MESH]|Drug Interactions[MESH]|Dyspnea/chemically induced[MESH]|Female[MESH]|Flushing/chemically induced[MESH]|Gastrointestinal Agents/administration & dosage/*adverse effects[MESH]|Humans[MESH]|Immunosuppressive Agents/adverse effects[MESH]|Infliximab[MESH]|Infusions, Intravenous[MESH]|Male[MESH]|Predictive Value of Tests[MESH]|Retrospective Studies[MESH]|Risk Factors[MESH]|Treatment Outcome[MESH] |