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  • Photolyase/cryptochrome blue-light photoreceptors use photon energy to repair DNA and reset the circadian clock
  • Thompson CL; Sancar A
  • Oncogene 2002[Dec]; 21 (58): 9043-56
  • Blue light governs a number of cellular responses in bacteria, plants, and animals, including photoreactivation, plant development, and circadian photoentrainment. These activities are mediated by a family of highly conserved flavoproteins, the photolyase/cryptochrome family. Photolyase binds to UV photoproducts in DNA and repairs them in a process called photoreactivation in which blue light is used to initiate a cyclic electron transfer to break bonds and restore the integrity of DNA. Cryptochrome, which has a high degree of sequence identity to photolyase, works as the main circadian photoreceptor and as a component of the molecular clock in animals, including mammals, and regulates growth and development in plants.
  • |*Drosophila Proteins[MESH]
  • |*Eye Proteins[MESH]
  • |*Photoreceptor Cells, Invertebrate[MESH]
  • |Amino Acid Sequence[MESH]
  • |Animals[MESH]
  • |Circadian Rhythm/*physiology[MESH]
  • |Cryptochromes[MESH]
  • |DNA Repair/*physiology[MESH]
  • |Deoxyribodipyrimidine Photo-Lyase/chemistry/genetics/*metabolism[MESH]
  • |Flavoproteins/genetics/*metabolism[MESH]
  • |Mammals[MESH]
  • |Molecular Sequence Data[MESH]
  • |Photons[MESH]
  • |Plant Proteins/chemistry/genetics/metabolism[MESH]
  • |Protein Conformation[MESH]
  • |Pyrimidine Dimers/metabolism[MESH]
  • |Receptors, G-Protein-Coupled[MESH]
  • |Sequence Homology, Amino Acid[MESH]





  • *{{pmid12483519}}
    *<b>[http://www.kidney.de/mlpefetch.php?search=12483519 Photolyase/cryptochrome blue-light photoreceptors use photon energy to repair DNA and reset the circadian clock ]</b> Oncogene 2002; 21(58) ; 9043-56 Thompson CL; Sancar A

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    Oncogene

    9043 58.21 2002