Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Homologous repair of DNA damage and tumorigenesis: the BRCA connection Jasin MOncogene 2002[Dec]; 21 (58): 8981-93Homologous recombination has been recognized in recent years to be an important DNA repair pathway in mammalian cells, for such damage as chromosomal double-strand breaks. Cells mutated for the genes involved in the hereditary breast and ovarian cancer susceptibility syndromes, i.e. BRCA1 and BRCA2, show defects in DNA repair by homologous recombination, implicating this repair pathway in protecting individuals against tumorigenesis. This review summarizes recent advances in our understanding of BRCA1 and BRCA2 in DNA repair, as well as insight into these proteins gleaned from structure determination of domains of these proteins and the broader evolutionary conservation than previously appreciated.|*Tumor Suppressor Proteins[MESH]|*Ubiquitin-Protein Ligases[MESH]|Amino Acid Sequence[MESH]|Animals[MESH]|BRCA1 Protein/*genetics/metabolism[MESH]|BRCA2 Protein/*genetics/metabolism[MESH]|Breast Neoplasms/genetics[MESH]|Carrier Proteins/genetics/metabolism[MESH]|Conserved Sequence[MESH]|DNA Damage/*physiology[MESH]|DNA Repair/*physiology[MESH]|DNA-Binding Proteins/genetics/metabolism[MESH]|Female[MESH]|Humans[MESH]|Mutation[MESH]|Neoplasms/*genetics[MESH]|Ovarian Neoplasms/genetics[MESH]|Rad51 Recombinase[MESH]|Recombination, Genetic[MESH] |