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lüll Studying the pathogenesis of BCR-ABL+ leukemia in mice Van Etten RAOncogene 2002[Dec]; 21 (56): 8643-51Animal models of BCR-ABL+ leukemias have provided important new knowledge about the molecular pathophysiology of these diseases, and answered questions that are difficult or impossible to address using BCR-ABL-expressing cell lines or primary Ph+ leukemia samples from patients. The power of mouse models lies in their ability to recapitulate precisely the phenotypes of BCR-ABL+ leukemias in vivo, but this comes at the price of significant complexity. Here I review recent studies of leukemias induced in mice by BCR-ABL with an emphasis on the intricate nature of these diseases and the need for careful pathological and molecular analysis.|Animals[MESH]|Disease Models, Animal[MESH]|Fusion Proteins, bcr-abl[MESH]|Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*etiology/*genetics[MESH]|Mice[MESH]|Protein-Tyrosine Kinases/*genetics[MESH] |