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Post-transcriptional mechanisms in BCR/ABL leukemogenesis: role of shuttling RNA-binding proteins Perrotti D; Calabretta BOncogene 2002[Dec]; 21 (56): 8577-83Shuttling hnRNPs control the fate of eukaryotic mRNAs throughout their journey from the active site of transcription to that of translation; thus, gain or loss of their function in hematopoietic cells might result in altered hematopoiesis and/or be associated with the process of leukemogenesis. In BCR/ABL-expressing cells, there is a marked increase in the protein levels FUS, hnRNP A1 and hnRNP E2, three RNA-binding proteins involved in the regulation of mRNA processing, nucleocytoplasmic export, and translation. Ectopic expression and/or inhibition of the activity of these RNA-binding proteins affects proliferation, survival, and differentiation of normal and BCR/ABL-expressing cells, suggesting that enhanced expression/activity of certain RNA-binding proteins plays an important, but as yet unrecognized, role in BCR/ABL leukemogenesis. The identification of the mRNA subsets associated with RNA-binding proteins upregulated in BCR/ABL-expressing cells should functionally link the process of leukemogenesis with alteration of mRNA metabolism.|*RNA Processing, Post-Transcriptional[MESH]|Fusion Proteins, bcr-abl[MESH]|Humans[MESH]|Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*metabolism/pathology/physiopathology[MESH]|Protein-Tyrosine Kinases/*metabolism[MESH]|RNA-Binding Proteins/*physiology[MESH] |
