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lüll Prevalence of melanoma clinically resembling seborrheic keratosis: analysis of 9204 cases Izikson L; Sober AJ; Mihm MC Jr; Zembowicz AArch Dermatol 2002[Dec]; 138 (12): 1562-6OBJECTIVE: To estimate the prevalence of melanoma clinically mimicking seborrheic keratosis. DESIGN: Retrospective review of cases submitted for histological examination with a clinical diagnosis of seborrheic keratosis or with a differential diagnosis that included seborrheic keratosis. SETTING: A tertiary medical care center-based dermatopathology laboratory serving academic dermatology clinics that have a busy pigmented lesion clinic. MATERIALS AND METHODS: A total of 9204 consecutive pathology reports containing a diagnosis of seborrheic keratosis in the clinical information field were identified between the years 1992 and 2001 through a computer database search. Reports with a final histological diagnosis of melanoma were selected for further review and clinicopathological analysis. MAIN OUTCOME MEASURE: Histological diagnosis, which was correlated with the preoperative clinical diagnosis. RESULTS: Melanoma was identified in 61 cases (0.66%) submitted for histological examination with a clinical diagnosis that included seborrheic keratosis. Melanoma was in the clinical differential diagnosis of 31 cases (51%). The remaining lesions had a differential diagnosis of seborrheic keratosis vs melanocytic nevus (17 cases, 28%), basal cell carcinoma (7 cases, 12%), or a squamous proliferation (3 cases, 5%). In 3 cases (5%), seborrheic keratosis was the only clinical diagnosis. All histological types of melanoma were represented. CONCLUSIONS: Our results confirm that melanoma can mimic seborrheic keratosis. These data strongly support the current policy of submitting for histological examination all specimens that have been removed from patients.|Adult[MESH]|Age Distribution[MESH]|Aged[MESH]|Biopsy, Needle[MESH]|Diagnosis, Differential[MESH]|Female[MESH]|Humans[MESH]|Immunohistochemistry[MESH]|Keratosis, Seborrheic/diagnosis/*epidemiology/*pathology[MESH]|Male[MESH]|Melanoma/diagnosis/*epidemiology/*pathology[MESH]|Middle Aged[MESH]|Prevalence[MESH]|Prognosis[MESH]|Retrospective Studies[MESH]|Sex Distribution[MESH]|Skin Neoplasms/diagnosis/*epidemiology/*pathology[MESH] |