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Long-term follow-up of 246 adults with juvenile idiopathic arthritis: functional outcome Packham JC; Hall MARheumatology (Oxford) 2002[Dec]; 41 (12): 1428-35OBJECTIVE: To examine the clinical and functional outcome of adults with juvenile idiopathic arthritis (JIA) using the recent World Health Organization/International League Against Rheumatism (ILAR) classification. PATIENTS AND METHODS: Two hundred and fifty-nine adults with long-standing JIA (average disease duration 28.3 yr) were eligible for the study; 246 (95%) attended for an interview, clinical examination and notes review and 231 (89.2%) returned a comprehensive functional and psychosocial self-assessment questionnaire. RESULTS: Of all patients, 43.3% had active arthritis clinically and 54.4% on laboratory measures (C-reactive protein). Clinical inflammation was less common in systemic-onset JIA. The percentage of all patients with severe disability (Health Assessment Questionnaire score >1.5) was 42.9. Uveitis occurred frequently in the oligoarticular-onset and enthesitis-related subsets. Over 30% of the extended oligoarticular group with uveitis developed glaucoma compared with none of the enthesitis group. CONCLUSIONS: Adults with JIA often have significant levels of disability, often related to continuing active disease over prolonged periods. There is a clear need for good transition from paediatric to high-quality adult rheumatology care.|*Arthritis, Juvenile/complications/immunology[MESH]|*Health Status[MESH]|Adolescent[MESH]|Adult[MESH]|Age of Onset[MESH]|Aged[MESH]|Amyloidosis/complications[MESH]|Anti-Inflammatory Agents, Non-Steroidal/therapeutic use[MESH]|Antibodies, Antinuclear/analysis[MESH]|Antirheumatic Agents/therapeutic use[MESH]|Blood Sedimentation[MESH]|C-Reactive Protein/analysis[MESH]|Chronic Disease[MESH]|Disability Evaluation[MESH]|Female[MESH]|Follow-Up Studies[MESH]|Growth Disorders/complications[MESH]|Humans[MESH]|Immunoglobulin G/blood[MESH]|Joints/physiopathology[MESH]|Male[MESH]|Middle Aged[MESH]|Uveitis/complications[MESH] |
