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lüll Cyclin destruction in mitosis: a crucial task of Cdc20 Irniger SFEBS Lett 2002[Dec]; 532 (1-2): 7-11Proteolytic destruction of cyclins is a fundamental process for cell division. At the end of mitosis, degradation of mitotic cyclins results in the inactivation of cyclin-dependent kinases. Cyclin proteolysis is triggered by the anaphase-promoting complex/cyclosome (APC/C), a multi-subunit complex which contains ubiquitin ligase activity. Recent data in yeast demonstrated that a partial degradation of the mitotic cyclin Clb2, mediated by APC/C and its activator protein Cdc20, is essential and sufficient for the mitotic exit. Remarkably, a complete inactivation of cyclin-dependent kinases seems to be not essential. This review discusses recent novel insights into cyclin destruction and its implications for the mitotic exit.|*Protein Tyrosine Phosphatases[MESH]|Animals[MESH]|CDC2 Protein Kinase/metabolism[MESH]|Cdc20 Proteins[MESH]|Cdh1 Proteins[MESH]|Cell Cycle Proteins/*physiology[MESH]|Cyclin B/metabolism[MESH]|Cyclins/*metabolism[MESH]|Drosophila Proteins[MESH]|Drosophila/metabolism[MESH]|Fungal Proteins/metabolism/*physiology[MESH]|Mitosis[MESH]|Models, Biological[MESH]|Saccharomyces cerevisiae Proteins/physiology[MESH] |