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Lipoprotein lipase: genetics, lipid uptake, and regulation Merkel M; Eckel RH; Goldberg IJJ Lipid Res 2002[Dec]; 43 (12): 1997-2006Lipoprotein lipase (LPL) regulates the plasma levels of triglyceride and HDL. Three aspects are reviewed. 1) Clinical implications of human LPL gene variations: common mutations and their effects on plasma lipids and coronary heart disease are discussed. 2) LPL actions in the nervous system, liver, and heart: the discussion focuses on LPL and tissue lipid uptake. 3) LPL gene regulation: the LPL promoter and its regulatory elements are described.|Chylomicrons/blood[MESH]|Gene Expression Regulation/physiology[MESH]|Genetic Variation[MESH]|Humans[MESH]|Lipoprotein Lipase/*genetics/metabolism[MESH]|Liver/*metabolism[MESH]|Mutation[MESH]|Myocardium/metabolism[MESH]|Nervous System/metabolism[MESH]|Organ Specificity[MESH] |
