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Genetic basis of neural tube defects II Genes correlated with folate and methionine metabolism Gos M Jr; Szpecht-Potocka AJ Appl Genet 2002[]; 43 (4): 511-24Effective supplementation with folate, which prevents neural tube defect (NTD) occurrence, and high homocysteine levels in the blood of NTD children's mothers suggest that genes involved in folate and homocysteine metabolism can be involved in NTD aetiology. Genes encoding methylenetetrahydrofolate reductase (MTHFR) or methylenetetrahydrofolate dehydrogenase (MTHFD) belong to the first group. Genes encoding methionine synthase (MTR), its regulator - methionine synthase reductase (MTRR) and also cystathionine synthase (CBS) can be included in the second group. We present a current list of the folate and homocysteine metabolism genes that are known to be involved in NTD and pay special attention to primary and secondary NTD prevention.|*Receptors, Cell Surface[MESH]|5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase/genetics/metabolism[MESH]|Animals[MESH]|Carrier Proteins/genetics/metabolism[MESH]|Cystathionine beta-Synthase/genetics/metabolism[MESH]|Ferredoxin-NADP Reductase/genetics/metabolism[MESH]|Folate Receptors, GPI-Anchored[MESH]|Folic Acid/*metabolism[MESH]|Humans[MESH]|Methionine/*metabolism[MESH]|Methylenetetrahydrofolate Dehydrogenase (NADP)/genetics/metabolism[MESH]|Methylenetetrahydrofolate Reductase (NADPH2)[MESH]|Mice[MESH]|Multifactorial Inheritance[MESH]|Neural Tube Defects/enzymology/etiology/*genetics/prevention & control[MESH]|Oxidoreductases Acting on CH-NH Group Donors/genetics/metabolism[MESH] |
