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lüll The restriction point of the cell cycle Blagosklonny MV; Pardee ABCell Cycle 2002[Mar]; 1 (2): 103-10As formulated in 1974, the concept of the restriction point of the cell cycle was based on cell biological experiments, yet allowing accurate molecular predictions and spurring a search for the restriction factor. Although cyclin D meets the criteria of the R-factor, the picture as outlined here is more interesting and far more complex. We discuss the relationship between the restriction knot and DNA damage-checkpoints. Finally, we discuss how loss of the restriction point in cancer leads to loss of checkpoint control and to insensitivity to antimitogens including some mechanism-based anticancer therapeutics.|*Signal Transduction[MESH]|Animals[MESH]|Cell Cycle/*physiology[MESH]|Cell Division[MESH]|Cyclin D[MESH]|Cyclin D1/metabolism[MESH]|Cyclin E/metabolism[MESH]|Cyclin-Dependent Kinases/antagonists & inhibitors[MESH]|Cyclins/metabolism[MESH]|Feedback, Physiological[MESH]|G1 Phase[MESH]|Humans[MESH]|MAP Kinase Signaling System[MESH]|Mitogens[MESH]|Proto-Oncogene Proteins c-myc/metabolism[MESH] |