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lüll Functional heartburn: the stimulus, the pain, and the brain Fass R; Tougas GGut 2002[Dec]; 51 (6): 885-92Functional heartburn is a common disorder and appears to be composed of several distinct subgroups. Identifying the different subgroups based on clinical history only is not achievable at present. The mechanisms responsible for pain, clinical characteristics, and the optimal therapeutic approach remain poorly understood. Response to potent antireflux treatment is relatively limited. Current and future treatment strategies for functional heartburn patients who have failed standard dose proton pump inhibitors (PPIs) include increased PPI dose in some, as well as addition of pain modulators in others.|Anti-Ulcer Agents/therapeutic use[MESH]|Esophagus/innervation[MESH]|Female[MESH]|Gastroesophageal Reflux/*complications/diagnosis/drug therapy[MESH]|Heartburn/diagnosis/drug therapy/*etiology[MESH]|Humans[MESH]|Male[MESH]|Proton Pump Inhibitors[MESH]|Selective Serotonin Reuptake Inhibitors/therapeutic use[MESH]|Sensation[MESH]|Serotonin Antagonists/therapeutic use[MESH] |