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The current status of neutrophil cytoplasmic antibodies van der Woude FJ; Daha MR; van Es LAClin Exp Immunol 1989[Nov]; 78 (2): 143-8Several studies in the past 10 years have demonstrated the occurrence of autoantibodies against cytoplasmic constituents in patients with vasculitis and glomerulonephritis. In this review the nomenclature of these antibodies is discussed and assays and clinical associations are summarized. Although the antigens involved are not completely identified, antibodies and T cells reactive with myeloid lysozomal enzymes may both play a significant role in pathogenesis.|*Antibodies, Antineutrophil Cytoplasmic/classification[MESH]|Autoantigens[MESH]|Glomerulonephritis/immunology[MESH]|Humans[MESH]|Immunoassay/methods[MESH]|Models, Immunological[MESH]|Terminology as Topic[MESH]|Vasculitis/immunology[MESH] |
