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CD20-mediated apoptosis: signalling through lipid rafts Deans JP; Li H; Polyak MJImmunology 2002[Oct]; 107 (2): 176-82CD20 is an effective target for therapeutic B-cell depletion with monoclonal antibodies. One proposed mechanism of action is direct cytotoxicity mediated via tyrosine kinase-dependent signalling pathways activated upon CD20 cross-linking. The association of CD20 with membrane microdomains known as lipid rafts, enriched in src-family tyrosine kinases and other signalling effectors, suggests an indirect mechanism of anti-CD20-induced apoptosis in which activation of src-family kinases occurs as a consequence of lipid raft clustering.|Amino Acid Sequence[MESH]|Animals[MESH]|Antigens, CD20/genetics/*immunology[MESH]|Apoptosis/*immunology[MESH]|Humans[MESH]|Membrane Microdomains/*immunology[MESH]|Molecular Sequence Data[MESH]|Signal Transduction/*immunology[MESH] |
