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The eye photoreceptor protein rhodopsin Structural implications for retinal disease Garriga P; Manyosa JFEBS Lett 2002[Sep]; 528 (1-3): 17-22Rhodopsin is the membrane receptor responsible for photoreception in the vertebrate retina. Its characteristic seven-transmembrane helical structural motif is today widely recognised as a paradigm in signal transduction. Rhodopsin and the phototransduction system are frequently used as structural and mechanistic models for the G-protein coupled receptor superfamily. Recent advances in the activation mechanism (as derived from the structural available data) and the implications for normal and pathological - in retinal disorders - visual function will be reviewed.|Amino Acid Sequence[MESH]|Animals[MESH]|Humans[MESH]|Models, Molecular[MESH]|Molecular Sequence Data[MESH]|Mutation[MESH]|Night Blindness/congenital/genetics/physiopathology[MESH]|Protein Structure, Secondary[MESH]|Retinal Diseases/genetics/*physiopathology[MESH]|Retinitis Pigmentosa/genetics/physiopathology[MESH]|Rhodopsin/*chemistry/genetics/*physiology[MESH]|Vision, Ocular[MESH] |
