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  • The dual function of the splenic marginal zone: essential for initiation of anti-TI-2 responses but also vital in the general first-line defense against blood-borne antigens
  • Zandvoort A; Timens W
  • Clin Exp Immunol 2002[Oct]; 130 (1): 4-11
  • The splenic marginal zone (S-MZ) is especially well equipped for rapid humoral responses and is unique in its ability to initiate an immune response to encapsulated bacteria (T-cell independent type 2 (TI-2) antigens). Because of the rapid spreading through the blood, infections with blood-borne bacteria form a major health risk. To cope with blood-borne antigens, a system is needed that can respond rapidly to a great diversity of organisms. Because of a number of unique features, S-MZ B cells can respond rapid and efficient to all sorts of blood-borne antigens. These unique features include a low blood flow microenvironment, low threshold for activation, high expression of complement receptor 2 (CR2, CD21) and multireactivity. Because of the unique high expression of CD21 in a low flow compartment, S-MZ B cells can bind and respond to TI-2 antigens even with relatively low-avid B cell receptors. Although TI-2 antigens are in general poorly opsonized by classic opsonins, a particular characteristic of these antigens is their ability to bind very rapidly to complement fragment C3d without the necessity of previous immunoglobulin binding. TI-2 primed S-MZ B cells, already by first passage through the germinal centre, will meet antigen-C3d complexes bound to follicular dendritic cells, allowing unique immediate isotype switching. This explains that the primary humoral response to TI-2 antigens is unique in its characterization by a rapid increase in IgM concurrent with IgG antibody levels.
  • |*Blood-Borne Pathogens[MESH]
  • |Adult[MESH]
  • |Animals[MESH]
  • |Antigen-Antibody Complex/immunology[MESH]
  • |Antigens, CD/immunology[MESH]
  • |Antigens, CD19/immunology[MESH]
  • |Antigens, Differentiation/immunology[MESH]
  • |Antigens, T-Independent/*immunology[MESH]
  • |B-Lymphocyte Subsets/immunology[MESH]
  • |Complement C3d/immunology[MESH]
  • |Disease Susceptibility[MESH]
  • |Humans[MESH]
  • |Immunoglobulin Class Switching[MESH]
  • |Immunoglobulin M/biosynthesis[MESH]
  • |Immunologic Memory/immunology[MESH]
  • |Infant[MESH]
  • |Lymphocyte Activation[MESH]
  • |Macromolecular Substances[MESH]
  • |Membrane Proteins/immunology[MESH]
  • |Mice[MESH]
  • |Mice, Mutant Strains[MESH]
  • |Mice, Nude[MESH]
  • |Receptors, Complement 3d/immunology[MESH]
  • |Spleen/blood supply/*immunology/microbiology/ultrastructure[MESH]
  • |Splenectomy/adverse effects[MESH]
  • |Tetraspanin 28[MESH]





  • *{{pmid12296846}}
    *<b>[http://www.kidney.de/mlpefetch.php?search=12296846 The dual function of the splenic marginal zone: essential for initiation of anti-TI-2 responses but also vital in the general first-line defense against blood-borne antigens ]</b> Clin Exp Immunol 2002; 130(1) ; 4-11 Zandvoort A; Timens W

        *12296846*

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    Clin Exp Immunol

    4 1.130 2002