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Methoden zur Bestimmung des Faktors XIII/XIIIa Wilmer M; Schroder V; Kohler HPHamostaseologie 2002[Feb]; 22 (1): 32-42Activated factor XIII (FXIIIa) plays an important role in the final stage of the coagulation cascade by covalent crosslinking of fibrin strands. As a transglutaminase FXIIIa catalyses the generation of intermolecular amide bonds between lysine and glutamine residues resulting in a complex three-dimensional clot structure. Enhanced clot stability is supported by covalent binding of cytosceleton factors like actin and myosin. Moreover, the clot is protected against premature lysis by the incorporation of fibrinolysis inhibitors like alpha(2)-antiplasmin and thrombin activatable fibrinolysis inhibitor (TAFI). A covalent crosslinking of the fibrin strands with extra-cellular matrix proteins like fibronectin, vitronectin, collagen and von Willebrand factor (vWF) immobilizes the clot at the site of injury. Moreover FXIII supports the healing process of damaged tissue. In this review assays for determination of FXIIIa activity, FXIII concentration and identification of the FXIIIVal34Leu polymorphism are shown.|Blood Coagulation/physiology[MESH]|Factor XIII/*analysis[MESH]|Factor XIIIa/*analysis[MESH]|Humans[MESH]|Kinetics[MESH] |
