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lüll Nasopharyngeal carcinoma Chan AT; Teo PM; Johnson PJAnn Oncol 2002[Jul]; 13 (7): 1007-15Nasopharyngeal carcinoma (NPC) is endemic in southern China where genetic abnormalities and Epstein-Barr virus (EBV) infection are critical in the pathogenesis of the disease. Circulating EBV-DNA has been shown to improve prognostication and monitoring of NPC patients. Radiotherapy is the mainstay treatment for early disease and concurrent cisplatin/radiotherapy has been demonstrated to prolong survival in locoregionally advanced disease. Ongoing studies of targeting agents and immunotherapeutic approaches may further improve treatment results.|Antineoplastic Combined Chemotherapy Protocols/*administration & dosage[MESH]|Biomarkers, Tumor/*analysis[MESH]|Biopsy, Needle[MESH]|Brachytherapy/*methods[MESH]|Carcinoma/mortality/*pathology/*therapy[MESH]|China/epidemiology[MESH]|Combined Modality Therapy[MESH]|DNA, Bacterial/*analysis[MESH]|Female[MESH]|Herpesvirus 4, Human/*isolation & purification[MESH]|Humans[MESH]|Immunotherapy/*methods[MESH]|Male[MESH]|Nasopharyngeal Neoplasms/epidemiology/*pathology/*therapy[MESH]|Neoplasm Staging[MESH]|Prognosis[MESH]|Randomized Controlled Trials as Topic[MESH]|Risk Assessment[MESH]|Survival Analysis[MESH]|Treatment Outcome[MESH] |