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The cell cycle as a target for cancer therapy: basic and clinical findings with the small molecule inhibitors flavopiridol and UCN-01 Senderowicz AMOncologist 2002[]; 7 Suppl 3 (ä): 12-9Many tumor types are associated with genetic changes in the retinoblastoma pathway, leading to hyperactivation of cyclin-dependent kinases and incorrect progression through the cell cycle. Small-molecule cyclin-dependent kinase inhibitors are being developed as therapeutic agents. Of these, flavopiridol and UCN-01 are being explored in cancer patients in phase I and phase II clinical trials, both as single agents and in combination with conventional chemotherapeutic agents. The present article discusses the mechanisms of action of flavopiridol and UCN-01 as well as the outcome of clinical trials with these novel agents.|Alkaloids/*pharmacology[MESH]|Animals[MESH]|Antineoplastic Agents/*pharmacology[MESH]|Cell Cycle/*drug effects[MESH]|Clinical Trials as Topic[MESH]|Cyclin-Dependent Kinases/*antagonists & inhibitors[MESH]|Enzyme Inhibitors/*pharmacology[MESH]|Flavonoids/*pharmacology[MESH]|Humans[MESH]|Neoplasms/*drug therapy[MESH]|Piperidines/*pharmacology[MESH]|Staurosporine/analogs & derivatives[MESH] |
