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Systemic sclerosis-scleroderma Haustein UFDermatol Online J 2002[Jun]; 8 (1): 3Systemic sclerosis is a clinically heterogeneous, systemic disorder which affects the connective tissue of the skin, internal organs and the walls of blood vessels. It is characterized by alterations of the microvasculature, disturbances of the immune system and by massive deposition of collagen and other matrix substances in the connective tissue. This review discusses epidemiology and survival, clinical features including subsets and internal organ involvement, pathophysiology and genetics, microvasculature, immunobiology, fibroblasts and connective tissue metabolism and environmental factors. Early diagnosis and individually tailored therapy help to manage this disorder, which is treatable, but not curable. Therapy involves immunomodulation as well as the targeting of blood vessel mechanics and fibrosis. Physical therapy and psychotherapy are also important adjunctive therapies in this multifactorial disease.|*Scleroderma, Systemic/diagnosis/epidemiology/etiology/physiopathology[MESH]|Animals[MESH]|Humans[MESH]|Risk Factors[MESH]|Sex Factors[MESH] |
