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lüll Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression Wenger RHFASEB J 2002[Aug]; 16 (10): 1151-62Although it was known for a long time that oxygen deprivation leads to the transcriptional induction of the gene encoding erythropoietin, the molecular mechanisms behind this process remained enigmatic. The cloning of the hypoxia-inducible factors (HIFs), the finding that HIF-1 regulates the expression of many more genes apart from erythropoietin, and the elucidation of the oxygen-dependent mechanisms degrading the HIF alpha subunits recently led to the spectacular discovery of the molecular principles of oxygen sensing. This review aims to summarize our current knowledge of oxygen-regulated gene expression..|*Receptors, Aryl Hydrocarbon[MESH]|*Tumor Suppressor Proteins[MESH]|*Ubiquitin-Protein Ligases[MESH]|Adaptation, Physiological[MESH]|Animals[MESH]|Aryl Hydrocarbon Receptor Nuclear Translocator[MESH]|Cell Hypoxia[MESH]|DNA-Binding Proteins/genetics/*metabolism/physiology[MESH]|Glucose/metabolism[MESH]|Humans[MESH]|Hypoxia-Inducible Factor 1[MESH]|Hypoxia-Inducible Factor 1, alpha Subunit[MESH]|Iron/metabolism[MESH]|Ligases/metabolism[MESH]|Mixed Function Oxygenases/*metabolism[MESH]|Nuclear Proteins/genetics/*metabolism/physiology[MESH]|Oxygen/*metabolism/*physiology[MESH]|Transcription Factors/genetics/*metabolism/physiology[MESH]|Transcriptional Activation[MESH]|Von Hippel-Lindau Tumor Suppressor Protein[MESH] |