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lüll 2-aminoethoxydiphenyl borate (2-APB) is a reliable blocker of store-operated Ca2+ entry but an inconsistent inhibitor of InsP3-induced Ca2+ release Bootman MD; Collins TJ; Mackenzie L; Roderick HL; Berridge MJ; Peppiatt CMFASEB J 2002[Aug]; 16 (10): 1145-50Since its introduction to Ca2+ signaling in 1997, 2-aminoethoxydiphenyl borate (2-APB) has been used in many studies to probe for the involvement of inositol 1,4,5-trisphosphate receptors in the generation of Ca2+ signals. Due to reports of some nonspecific actions of 2-APB, and the fact that its principal antagonistic effect is on Ca2+ entry rather than Ca2+ release, this compound may not have the utility first suggested. However, 2-APB has thrown up some interesting results, particularly with respect to store-operated Ca2+ entry in nonexcitable cells. These data indicate that although it must be used with caution, 2-APB can be useful in probing certain aspects of Ca2+ signaling.|Animals[MESH]|Boron Compounds/*pharmacology[MESH]|Calcium Channel Blockers/*pharmacology[MESH]|Calcium Channels/metabolism[MESH]|Calcium Signaling/drug effects[MESH]|Calcium/*metabolism[MESH]|Inositol 1,4,5-Trisphosphate Receptors[MESH]|Inositol 1,4,5-Trisphosphate/*antagonists & inhibitors[MESH]|Ion Transport/drug effects[MESH]|Macrocyclic Compounds[MESH]|Mice[MESH]|Oxazoles/pharmacology[MESH]|Receptors, Cytoplasmic and Nuclear/metabolism[MESH] |