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PAX genes in development and disease: the role of PAX2 in urogenital tract development Eccles MR; He S; Legge M; Kumar R; Fox J; Zhou C; French M; Tsai RWInt J Dev Biol 2002[]; 46 (4): 535-44PAX genes play an important role in fetal development. Moreover, heterozygous mutations in several PAX genes cause human disease. Here we review the role of PAX2 in kidney development, focusing on the morphological effects of PAX2 mutations. We discuss the role of PAX2 in the context of an inhibitory field model of kidney branching morphogenesis and summarize recent progress in this area.|*Gene Expression Regulation, Developmental[MESH]|Animals[MESH]|Apoptosis[MESH]|Coloboma/*complications[MESH]|DNA-Binding Proteins/*biosynthesis/*physiology[MESH]|Female[MESH]|Heterozygote[MESH]|Homozygote[MESH]|Humans[MESH]|Immunohistochemistry[MESH]|Kidney/abnormalities/*embryology/metabolism[MESH]|Male[MESH]|Mice[MESH]|Microscopy, Fluorescence[MESH]|Models, Biological[MESH]|Models, Genetic[MESH]|Mutation[MESH]|Oligonucleotide Array Sequence Analysis[MESH]|Oviducts/metabolism[MESH]|PAX2 Transcription Factor[MESH]|Syndrome[MESH]|Transcription Factors/*biosynthesis/*physiology[MESH]|Urogenital System/*embryology[MESH] |
