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lüll Further checkpoints in Th1 development Robinson DS; O'Garra AImmunity 2002[Jun]; 16 (6): 755-8Tight control of Th1 immunity is essential to prevent immunopathology. Central to control of the IFN-gamma gene is the transcription factor T-bet, whose induction is Stat-1 dependent. IL-12 is dominant in directing Th1 development, while synergizing with IL-18 for IFNgamma production from differentiated Th1 cells. In this issue of Immunity, IL-27 is described, which acts in synergy with IL-12 early in Th1 development from naive T cells via the receptor TCCR/WSX-1. We review the coordination of these checkpoints in Th1 development and function.|*Receptors, Cytokine[MESH]|Glycoproteins/*physiology[MESH]|Humans[MESH]|Interleukin-12/*physiology[MESH]|Interleukin-18/*physiology[MESH]|Interleukins/*physiology[MESH]|Minor Histocompatibility Antigens[MESH]|Models, Biological[MESH]|Th1 Cells/*immunology[MESH] |