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The T-box family Wilson V; Conlon FLGenome Biol 2002[]; 3 (6): REVIEWS3008Transcription factors of the T-box family are required both for early cell-fate decisions, such as those necessary for formation of the basic vertebrate body plan, and for differentiation and organogenesis. When mutated, T-box genes give dramatic phenotypes in mouse and zebrafish, and they have been implicated both in fundamentals of limb patterning and in a number of human congenital malformations such as Holt-Oram, ulnar-mammary and DiGeorge syndromes, as well as being amplified in a subset of cancers. Genes encoding members of the T-box family have recently been shown to comprise approximately 0.1% of genomes as diverse as those of nematodes and humans and have been identified in a wide variety of animals from ctenophores (comb jellies) to mammals; they are, however, completely absent from genomes from other organisms (such as the model plant Arabidopsis thaliana).|Animals[MESH]|Computational Biology[MESH]|Evolution, Molecular[MESH]|Gene Expression Regulation/genetics[MESH]|Genes, Regulator/genetics[MESH]|Humans[MESH]|Multigene Family/*genetics[MESH]|Organ Specificity/genetics[MESH]|Protein Structure, Tertiary/genetics[MESH]|T-Box Domain Proteins/chemistry/*genetics[MESH] |
