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lüll Chemotactic signaling pathways in neutrophils: from receptor to actin assembly Cicchetti G; Allen PG; Glogauer MCrit Rev Oral Biol Med 2002[]; 13 (3): 220-8In this review, we present an overview of the signaling elements between neutrophil chemotactic receptors and the actin cytoskeleton that drives cell motility. From receptor-ligand interactions, activation of heterotrimeric G-proteins, their downstream effectors PLC and PI-3 kinase, the activation of small GTPases of the Rho family, and their regulation of particular cytoskeletal regulatory proteins, we describe pathways specific to the chemotaxing neutrophil and elements documented to be important for neutrophil function.|Actins/*metabolism/physiology[MESH]|Chemotactic Factors/*physiology[MESH]|Chemotaxis, Leukocyte/physiology[MESH]|Cytoskeleton/*metabolism/physiology[MESH]|GTP Phosphohydrolases/physiology[MESH]|GTP-Binding Proteins/physiology[MESH]|Humans[MESH]|Neutrophil Activation/physiology[MESH]|Neutrophil Infiltration/physiology[MESH]|Neutrophils/*physiology[MESH]|Phosphatidylinositol 3-Kinases/physiology[MESH]|Phosphatidylinositols/physiology[MESH]|Receptors, Cell Surface/*physiology[MESH]|Signal Transduction/*physiology[MESH]|Type C Phospholipases/physiology[MESH]|rho GTP-Binding Proteins/physiology[MESH] |