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lüll The evolution of monomeric and oligomeric betagamma-type crystallins Facts and hypotheses D'Alessio GEur J Biochem 2002[Jul]; 269 (13): 3122-30The case of homologous monomeric gamma-type and oligomeric beta-type crystallins has been described and analyzed in evolutionary terms. Data and hypotheses from molecular genetics and structural investigations converge and suggest a novel three-phase model for the evolutionary history of crystallin-type proteins. In the divergent cascades of monomeric and oligomeric crystallins, a pivotal role was played by alterations in the gene segments encoding the C-terminal extensions and the intermotif or interdomain linker peptides. These were genomic hot spots where evolution experimented to produce the modern variety of betagamma-crystallin-type quaternary structures.|*Evolution, Molecular[MESH]|Animals[MESH]|Crystallins/*chemistry/*genetics[MESH]|Dimerization[MESH]|Introns[MESH]|Models, Biological[MESH]|Models, Molecular[MESH]|Protein Conformation[MESH] |