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lüll First hundred cases of variant Creutzfeldt-Jakob disease: retrospective case note review of early psychiatric and neurological features Spencer MD; Knight RS; Will RGBMJ 2002[Jun]; 324 (7352): 1479-82OBJECTIVE: To describe the early psychiatric and neurological features of variant Creutzfeldt-Jakob disease. DESIGN: Cohort study. SETTING: National surveillance system for Creutzfeldt-Jakob disease in the United Kingdom. PARTICIPANTS: The first 100 cases of variant Creutzfeldt-Jakob disease identified in the United Kingdom. MAIN OUTCOME MEASURES: The timing and nature of early psychiatric and neurological symptoms in variant Creutzfeldt-Jakob disease. RESULTS: The early stages of variant Creutzfeldt-Jakob disease are dominated by psychiatric symptoms, but neurological symptoms precede psychiatric symptoms in 15% of cases and are present in combination with psychiatric symptoms in 22% of cases from the onset of disease. Common early psychiatric features include dysphoria, withdrawal, anxiety, insomnia, and loss of interest. No common early neurological features exist, but a significant proportion of patients do exhibit neurological symptoms within 4 months of clinical onset, including poor memory, pain, sensory symptoms, unsteadiness of gait, and dysarthria. CONCLUSIONS: Although the diagnosis of variant Creutzfeldt-Jakob disease may be impossible in the early stages of the illness, particular combinations of psychiatric and neurological features may allow early diagnosis in an appreciable proportion of patients.|Adolescent[MESH]|Adult[MESH]|Age of Onset[MESH]|Aged[MESH]|Child[MESH]|Cohort Studies[MESH]|Creutzfeldt-Jakob Syndrome/diagnosis/epidemiology/*psychology[MESH]|Humans[MESH]|Mental Disorders/*etiology[MESH]|Middle Aged[MESH]|Retrospective Studies[MESH]|Time Factors[MESH] |