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lüll Potential use of beta(3)-adrenoceptor antagonists in heart failure therapy Moniotte S; Balligand JLCardiovasc Drug Rev 2002[Win]; 20 (1): 19-26Recently, a functional, negatively inotropic, beta(3)-adrenoceptor was characterized in the human heart. Several studies now suggest that this receptor might play an important role in the pathophysiology of heart failure, by counterbalancing the effects of a beta(1)- and beta(2)-stimulation. Therefore, this review summarizes the rationale and effects of beta-adrenergic blockade in chronic heart failure and specifically addresses the question of the potential use of beta(3)-adrenoceptor antagonists in the treatment of heart failure and other pathophysiological conditions associated with a decreased cardiac contractility.|*Adrenergic beta-3 Receptor Antagonists[MESH]|Adrenergic beta-Antagonists/*therapeutic use[MESH]|Animals[MESH]|Autonomic Pathways/physiology[MESH]|Heart Failure/*drug therapy/metabolism[MESH]|Heart/drug effects/physiology[MESH]|Humans[MESH]|Receptors, Adrenergic, beta-3/physiology[MESH]|Sympathetic Nervous System/physiology[MESH] |