Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Cardiac sodium and calcium channels: a history of excitatory currents Fozzard HACardiovasc Res 2002[Jul]; 55 (1): 1-8The entire concept of ion channels as molecular machines to gate ion traffic across the membrane has only recently been generally recognized, even though ion channels are found in almost all cells. Na+ and Ca2+ channels are the basis of excitability, and in the heart they generate the rhythm, coordinating and controlling cardiac contraction. Dysfunction of ion channels results in arrhythmias that underlie 20-25% of deaths in the developed world, and some arrhythmias result directly from gene defects in ion channels. This is my personal perspective on the critical ideas and the pioneers in the field of cardiac Na+ and Ca2+ channels.|Action Potentials/physiology[MESH]|Animals[MESH]|Arrhythmias, Cardiac/*metabolism[MESH]|Humans[MESH]|Ion Channel Gating/*physiology[MESH]|Ion Channels/*metabolism[MESH]|Myocardium/*metabolism[MESH]|Patch-Clamp Techniques[MESH]|Research Design[MESH] |