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Molecular genetics of transmissible spongiform encephalopathies: an introduction Weissmann CJ Toxicol Sci 2002[May]; 27 (2): 69-77Prnp knockout mice disrupted PrPC-related genes have played an essential role to elucidate the relationship between PrPC, a normal host gene product, and PrPSc, a protease-resistant, infectious PrP; Prnp knockout mice developed by Bueler et al. (1992) were completely protected against scrapie disease when challenged with mouse prions. Further, varying expression levels in PrPC were revisited along with a varying susceptibility of mouse prions, when mouse Prnp genes were introduced into Prnp% mice. How these murine models for human prion-related disease would contribute to the presently ongoing TSE research?|Amyloid/*genetics[MESH]|Animals[MESH]|Creutzfeldt-Jakob Syndrome/genetics[MESH]|Disease Models, Animal[MESH]|Humans[MESH]|Mice[MESH]|Mice, Knockout[MESH]|Mutation[MESH]|PrPC Proteins/genetics[MESH]|PrPSc Proteins/genetics[MESH]|Prion Diseases/*genetics[MESH]|Prion Proteins[MESH]|Prions/*genetics/pathogenicity[MESH]|Protein Precursors/*genetics[MESH] |
