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DC-SIGN, a C-type lectin on dendritic cells that unveils many aspects of dendritic cell biology Geijtenbeek TB; Engering A; Van Kooyk YJ Leukoc Biol 2002[Jun]; 71 (6): 921-31Dendritic cells (DC) are present in essentially every tissue where they operate at the interface of innate and acquired immunity by recognizing pathogens and presenting pathogen-derived peptides to T cells. It is becoming clear that not all C-type lectins on DC serve as antigen receptors recognizing pathogens through carbohydrate structures. The C-type lectin DC-SIGN is unique in that it regulates adhesion processes, such as DC trafficking and T-cell synapse formation, as well as antigen capture. Moreover, even though several C-type lectins have been shown to bind HIV-1, DC-SIGN does not only capture HIV-1 but also protects it in early endosomes allowing HIV-1 transport by DC to lymphoid tissues, where it enhances trans infection of T cells. Here we discuss the carbohydrate/protein recognition profile and other features of DC-SIGN that contribute to the potency of DC to control immunity.|*Cell Adhesion Molecules[MESH]|*Lectins, C-Type[MESH]|Animals[MESH]|Dendritic Cells/*physiology[MESH]|Humans[MESH]|Lectins/*physiology[MESH]|Mice[MESH]|Receptors, Antigen/physiology[MESH]|Receptors, Cell Surface/*physiology[MESH]|Receptors, HIV/physiology[MESH] |
