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lüll The anaphase-promoting complex: proteolysis in mitosis and beyond Peters JMMol Cell 2002[May]; 9 (5): 931-43Key events in mitosis such as sister chromatid separation and subsequent inactivation of cyclin-dependent kinase 1 are regulated by ubiquitin-dependent proteolysis. These events are mediated by the anaphase-promoting complex (APC), a cell cycle-regulated ubiquitin ligase that assembles multiubiquitin chains on regulatory proteins such as securin and cyclins and thereby targets them for destruction by the 26S proteasome.|*Endopeptidases[MESH]|*Proteasome Endopeptidase Complex[MESH]|*Ubiquitin-Protein Ligase Complexes[MESH]|Anaphase-Promoting Complex-Cyclosome[MESH]|Animals[MESH]|Cell Cycle Proteins/metabolism[MESH]|Cyclins/physiology[MESH]|Ligases/*physiology[MESH]|Mitosis/*physiology[MESH]|Peptide Hydrolases/metabolism[MESH]|Separase[MESH]|Signal Transduction[MESH]|Transforming Growth Factor beta/physiology[MESH]|Ubiquitins/metabolism[MESH] |